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Estrogen receptor (ER) action is modulated by posttranslational modifications. Although ERα phosphorylation correlates with patient outcome, ERβ is similarly phosphorylated but its significance in breast cancer has not been addressed.
Following antibody validation, S105-ERbeta expression was studied in tissue microarrays comprising 108 tamoxifen-resistant and 351 tamoxifen-sensitive cases and analyzed against clinical data.S105-ERβ regulation was assessed by Western blot, flow cytometry, and immunofluorescence. C.), Leeds Teaching Hospitals NHS Trust Breast Fund (V. Nuclear S105-ERβ was observed in breast carcinoma and was associated with better survival (Allred score ≥3), even in tamoxifen-resistant cases, and additionally correlated with ERβ1 and ERβ2 expression. Distinct S105-ERβ nuclear speckles were seen in some higher grade tumors.
S105-ERβ levels increased in MCF-7 cells in response to 17β-estradiol, the ERβ-specific agonist diarylpropionitrile, and the partial ERβ-agonist genistein. Distinct S105-ERbeta nuclear speckles were seen in some higher grade tumors.